Toxicology & Pharmacology Conference to be held in Rome, Italy during March 23 - 24 2020.
Neurotoxicology
Get link
Facebook
X
Pinterest
Email
Other Apps
The term neurotoxicity refers to damage to the brain or peripheral nervous system caused by exposure to natural or man-made toxic substances. These toxins can alter the activity of the nervous system in ways that can disrupt or kill nerves. Nerves are essential for transmitting and processing information in the brain, as well as other areas of the nervous system. Due to their high metabolic rate, neurons are at the greatest risk of damage caused by neurotoxins. This is followed, in order of risk, by oligodendrocytes, astroocytes, microglia and capillary endothelium cells. Depending on a neurotoxin’s chemical profile, it will cause damage to certain parts or particular cellular elements of the nervous system. Non-polar substances are more soluble in lipids and can therefore access the nervous tissue more easily than polar compounds, which are less soluble in lipids. The body’s response to neurotoxins is influenced by factors such as the neurotransmitter affected, cellular membrane integrity and the presence of detoxifying mechanisms.
Metabolism is a biotransformation process, where endogenous and exogenous compounds are converted to more polar products to facilitate their elimination from the body. The process of metabolism is divided into 3 phases. Phase I metabolism involves functionalization reactions. Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or metabolites from body normally via liver, gut, kidney, or lung. This review presents basic information on drug-metabolizing enzymes and potential factors that might affect the metabolic capacities of the enzyme or alter drug response or drug-mediated toxicities . For more: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/ For abstract submission: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/submitabstract Contact us: toxicology@globalepisteme.com
Nanotoxicology is the study of the toxicity of nanomaterials. Because of quantum size effects and large surface area to volume ratio, nanomaterials have unique properties compared with their larger counterparts. Nanotoxicology is a branch of bionanoscience which deals with the study and application of toxicity of nanomaterials. Nanomaterials , even when made of inert elements like gold, become highly active at nanometer dimensions. Nanotoxicological studies are intended to determine whether and to what extent these properties may pose a threat to the environment and to human beings. For instance, Diesel nanoparticles have been found to damage the cardiovascular system in a mouse model. For more: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/ For abstract submission: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/submitabstract Contact us: toxicology@globalepisteme.com
Immunopharmacology is defined as that part of pharmacology that deals with drugs acting on the immune system and, in addition, with the pharmacological actions of substances derived from the immune system . In order to lend sharper definition to the term immunopharmacology the subject matter has been divided according to clinical and pragmatic criteria. The division into immunosubstituion, immunosuppression, antiallergic substances and immunostimulation gives the heterogeneous material a tighter structure than would any classification according to origin, chemical structure or mechanism of action. For more: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference For abstract submission: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/submitabstract Contact us: toxicology@globalepisteme.com
Comments
Post a Comment