Toxicology & Pharmacology Conference to be held in Rome, Italy during March 23 - 24 2020.
Neurotoxicology
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The term neurotoxicity refers to damage to the brain or peripheral nervous system caused by exposure to natural or man-made toxic substances. These toxins can alter the activity of the nervous system in ways that can disrupt or kill nerves. Nerves are essential for transmitting and processing information in the brain, as well as other areas of the nervous system. Due to their high metabolic rate, neurons are at the greatest risk of damage caused by neurotoxins. This is followed, in order of risk, by oligodendrocytes, astroocytes, microglia and capillary endothelium cells. Depending on a neurotoxin’s chemical profile, it will cause damage to certain parts or particular cellular elements of the nervous system. Non-polar substances are more soluble in lipids and can therefore access the nervous tissue more easily than polar compounds, which are less soluble in lipids. The body’s response to neurotoxins is influenced by factors such as the neurotransmitter affected, cellular membrane integrity and the presence of detoxifying mechanisms.
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may include the step of obtaining regulatory approval with a new drug application to market the drug For more: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/ For abstract submission: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/submitabstract Contact us: toxicology@globalepisteme.com
Aflatoxins are a family of toxins produced by certain fungi that are found on agricultural crops such as maize, peanuts, cottonseed, and tree nuts. The main fungi that produce aflatoxins are Aspergillus flavus and Aspergillus parasiticus , which are abundant in warm and humid regions of the world For more: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference For abstract submission: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/submitabstract Contact us: toxicology@globalepisteme.com
Metabolism is a biotransformation process, where endogenous and exogenous compounds are converted to more polar products to facilitate their elimination from the body. The process of metabolism is divided into 3 phases. Phase I metabolism involves functionalization reactions. Phase II drug metabolism is a conjugation reaction. Phase III refers to transporter-mediated elimination of drug and/or metabolites from body normally via liver, gut, kidney, or lung. This review presents basic information on drug-metabolizing enzymes and potential factors that might affect the metabolic capacities of the enzyme or alter drug response or drug-mediated toxicities . For more: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/ For abstract submission: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/submitabstract Contact us: toxicology@globalepisteme.com
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