Toxicology & Pharmacology Conference to be held in Rome, Italy during March 23 - 24 2020.
Forensic Toxicology
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Forensic toxicology is the use of toxicology and other disciplines such as analytical chemistry, pharmacology and clinical chemistry to aid medical or legal investigation of death, poisoning, and drug use. The primary concern for forensic toxicology is not the legal outcome of the toxicological investigation or the technology utilised, but rather the obtaining and interpreting of the results. A toxicological analysis can be done to various kinds of samples. A forensic toxicologist must consider the context of an investigation, in particular any physical symptoms recorded, and any evidence collected at a crime scene that may narrow the search, such as pill bottles, powders, trace residue, and any available chemicals. Provided with this information and samples with which to work, the forensic toxicologist must determine which toxic substances are present, in what concentrations, and the probable effect of those chemicals on the person. Determining the substance ingested is often complicated by the body's natural processes, as it is rare for a chemical to remain in its original form once in the body.
Drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity, efficacy/potency, metabolic stability, and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, the process of drug development can continue, and, if successful, clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. A toxicology screen is a test that determines the approximate amount and type of legal or illegal drugs that taken. It may be used to screen for drug abuse , to monitor a substance abuse problem, or to evaluate drug intoxication or overdose. Toxicology screening can be done fairly quickly. The test is most often done using a urine or blood sample. In some cases, a sample of saliva or hair may be used. The results can show the presence of one specific drug or a variety of drugs at once. Further testing may be needed to determ...
Drug safety in the development process, new biomarkers are needed which can reduce the time-consuming process and cost of drug development. Traditional indicators of target organ toxicity used in preclinical drug safety studies consist of a battery of clinical pathology parameters in blood and urine coupled with histopathologic examination of altered tissues. Researching the translational safety biomarker is a process that investigates one characteristic of the biomarker, i.e. noninvasive, and translates between species. The safety biomarker should be validated and preclinically and clinically qualified. Several kidney biomarkers in the context of preclinical development and clinical trials are presented in this chapter. Application of safety biomarkers in different phases of drug development, in particular for kidney, liver, heart, vascular vessels, lung, central nervous system, and lipid/carbohydrate metabolism, is described. For more: http://www.globalepisteme.org/Conferenc...
The goal of preclinical safety assessment should be to provide some assurance that patients will be protected from any unacceptable risks by defining safe and active doses. These data have been useful in providing some assurance that severe adverse effects would not be induced in patients. For more: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/ For abstract submission: http://www.globalepisteme.org/Conference/toxicology-pharmacology-conference/submitabstract Contact us: toxicology@globalepisteme.com
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