In-vitro and In-vivo Toxicology

An in vitro test is a study that is performed outside of a living organism. The test usually involves the use of isolated tissues, organs or cells. In contrast, an in vivo test is a study that is performed in living organisms. Both in vitro and in vivo methods can be used to predict the inherent hazard properties of chemical substances. However, results obtained from in vitro studies cannot often be used directly to predict biological responses of organisms to chemical exposure in vivo. That does not mean that in vitro data is of less value. In fact, in vitro test is gaining more attention in regulatory community since it can reduce the number of animals used significantly while offering reliable predictions for some toxicological endpoints.

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